本研究共挑选生物钟通路相关基因功能性 SNP 位点 55 个,除 rs2279286、rs939347 外、其余 SNPs 检出率均超过 95%。经哈迪温伯格平衡检验,7 个 SNP(rs11133399, rs3809235, rs3824872, rs939347, rs11588258, rs12045886, rs3027171)不符合哈迪温伯格平衡,如表 4 所示,有 48 个 SNP 位点被纳入后续的研究,其中有 5 个位于 ARNTL 上,4 个位于 CLOCK 上,4 个位于 CRY1 上,2 个位于CRY2 上,2 个位于 CSNK1D 上,2 个位于 NR1D1 上,5 个位于 PER1 上,3 个位于 PER2 上,3 个位于 PER3 上,3 个位于 RORA 上,6 个位于 RORB 上,9个位于 RORC 上。另外发现,RORB 上的 rs2273975、rs4376556 和 rs7846903位点的三种基因型在病例组和对照组中的分布差异有统计学意义(P=0.027、P=0.021、P=0.022)。
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